X-ray structure of a bacterial oligosaccharyltransferase

X-ray structure of a bacterial oligosaccharyltransferase

Nature 474, 7351 (2011). doi:10.1038/nature10151

Authors: Christian Lizak, Sabina Gerber, Shin Numao, Markus Aebi & Kaspar P. Locher

Asparagine-linked glycosylation is a post-translational modification of proteins containing the conserved sequence motif Asn-X-Ser/Thr. The attachment of oligosaccharides is implicated in diverse processes such as protein folding and quality control, organism development or host–pathogen interactions. The reaction is catalysed by oligosaccharyltransferase (OST), a membrane protein