Vaccine discovery and translation of new vaccine technology

Publication year: 2011
Source: The Lancet, In Press, Corrected Proof, Available online 12 June 2011

Rino, Rappuoli , Steven, Black , Paul Henri, Lambert

An unprecedented increase in new vaccine development has occurred over the past three decades. This activity has resulted in vaccines that protect against an increased range of vaccine-preventable diseases, vaccines that reduce the number of required injections, and vaccines with improved safety and purity. New methods of discovery, such as reverse vaccinology, structural biology, and systems biology, promise new vaccines for different diseases and efficient development pathways for these vaccines. We expect development of vaccines not only for infectious diseases in children but also for healthy adults, pregnant women, and elderly people, and for new indications such as autoimmune disease…