Urinary bisphenol A and obesity: NHANES 2003–2006☆

Publication year: 2011
Source: Environmental Research, In Press, Corrected Proof, Available online 14 June 2011

Jenny L., Carwile , Karin B., Michels

 Background: Bisphenol A (BPA) is a chemical suspected of causing endocrine and metabolic disruption in animals and humans. In rodents, in utero exposure to low-dose BPA is associated with weight gain. Detectable levels of BPA are found in most Americans due to its widespread use in the manufacture of food and drink packaging. We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity. Methods: Cross-sectional analysis of urinary BPA concentrations, body mass index, and waist circumference in 2747 adults (aged 18–74), using pooled data from the 2003/04 and 2005/06 National Health and Nutrition Examination Surveys. Results: The creatinine-adjusted geometric mean…

 Highlights: ► Association of urinary BPA with BMI and waist circumference in 2003–2006 NHANES. ► Participants in upper BPA quartiles 1.60–1.85 times are likely to be obese. ► Higher BPA concentration also associated with abdominal obesity. ► Prospective studies needed to clarify the direction of the association.