Toward a functional neuroanatomical signature of bipolar disorder: Quantitative evidence from the neuroimaging literature

Publication year: 2011
Source: Psychiatry Research: Neuroimaging, In Press, Corrected Proof, Available online 14 June 2011

David A., Kupferschmidt , Konstantine K., Zakzanis

The present meta-analysis quantitatively reviewed the functional neuroimaging literature on bipolar disorder (BPD) to better characterize its neuroanatomical signature with respect to the influence of mood state, test conditions, and clinical demographics on regional brain activation. Fifty-five functional neuroimaging studies published between 1987 and 2010 met criteria for inclusion, encompassing a total of 774 adult patients with BPD and 810 healthy adult controls. A meta-analysis was conducted comparing the activation states of multiple brain regions in BPD patients and control subjects. Despite heterogeneity across studies, our findings support the view that limbic hyperactivity and frontal hypoactivity are neurobiological correlates of…