Timing behavior in streptozotocin-induced diabetic rats.

Publication year: 2011
Source: Behavioural Brain Research, In Press, Accepted Manuscript, Available online 13 June 2011

Vladimir, Orduña , Enrique, Hong , Arturo, Bouzas

There is evidence of deterioration of spatial cognition in streptozotocin (STZ)-induced diabetic rats. Here, we evaluate a possible dissociation in the cognitive deficits due to diabetes by examining another crucial aspect of animal cognition: temporal perception. Timing behavior and temporal memory were evaluated in STZ-induced diabetic rats employing two timing tasks: the Peak- Interval procedure, with its Gap variant, and the Interval Bisection task. A spatial memory task, Rewarded Alternation in the T-maze, was also evaluated to explore spatial cognition. The two timing tasks employed coincide in the finding of a normal timing performance in STZ-induced diabetic rats. The peak-interval…

 Highlights: ► We explored the impact of diabetes on timing behavior and spatial cognition. ► A normal timing process was found in diabetic rats in the three timing tasks employed. ► In contrast, a deficit in spatial cognition was found in diabetic rats. ► Temporal and spatial cognition were differentially affected by diabetes.