The Newer Fluoroquinolones

Publication year: 2011
Source: Medical Clinics of North America, Volume 95, Issue 4, July 2011, Pages 793-817

Maureen K., Bolon

Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones—ciprofloxacin, levofloxacin, and moxifloxacin.