The contribution of vitamin a to autocrine regulation of fat depots☆

Publication year: 2011
Source: Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, In Press, Accepted Manuscript, Available online 13 June 2011

Rumana, Yasmeen , Shanmugam M., Jeyakumar , Barbara, Reichert , Fangping, Yang , Ouliana, Ziouzenkova

Morbidity and mortality associated with increased white fat accumulation in visceral fat depots has focused attention on the pathways regulating the development of this tissue during embryogenesis, in adulthood, and while under the influence of obesogenic diets. Adipocytes undergo clonal expansion, differentiation (adipogenesis) and maturation through a complex network of transcriptional factors, most of which are expressed at similar levels in visceral and subcutaneous fat. Rigorous research attempts to unfold the pathways regulating expression and activity of adipogenic transcription factors that act in a fat-depot-specific manner. Peroxisome proliferator-activated receptor-γ (PPARγ) is the master regulator of adipogenesis, and is expressed at…