Safety and tolerability of repetitive transcranial magnetic stimulation in patients with pathologic positive sensory phenomena: a review of literature

Publication year: 2011
Source: Brain Stimulation, In Press, Uncorrected Proof, Available online 14 June 2011

Paul A., Muller , Alvaro, Pascual-Leone , Alexander, Rotenberg

 Background: Repetitive transcranial magnetic stimulation (rTMS) is emerging as a valuable therapeutic and diagnostic tool. rTMS appears particularly promising for disorders characterized by positive sensory phenomena that are attributable to alterations in sensory cortical excitability. Among these are tinnitus, auditory and visual hallucinations, and pain syndromes. Objective: Despite studies addressing rTMS efficacy in suppression of positive sensory symptoms, the safety of stimulation of potentially hyperexcitable cortex has not been fully addressed. We performed a systematic literature review and metaanalysis to describe the rTMS safety profile in these disorders. Methods: Using the PubMed database, we performed an English-language literature search from January 1985 to April 2011…