Roles of avian herpesvirus microRNAs in infection, latency, and oncogenesis

Publication year: 2011
Source: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, In Press, Accepted Manuscript, Available online 13 June 2011

Robin W., Morgan , Joan, Burnside

MicroRNAs have been reported for the avian herpesviruses Marek’s disease virus 1 (MDV1; oncogenic), Marek’s disease virus 2 (MDV2; non-oncogenic), herpesvirus of turkeys (HVT), and infectious laryngotracheitis virus (ILTV). No obvious phylogenetic relationships exist among the avian herpesvirus microRNAs, but the general genomic locations of microRNA clusters are conserved, with microRNAs being located in the repeat regions of the genomes. In some cases, microRNAs are antisense to open reading frames. Among MDV1 field isolates with different virulence properties, microRNAs are highly conserved, and variations that have been observed lie in putative promoter regions. One cluster of MDV1 microRNAs lies upstream…

 Highlights: ► Avian herpesvirus microRNAs have been reported for MDV1, MDV2, HVT, and ILTV. ► Avian herpesvirus microRNA sequences are unique, but the general genomic locations of microRNA clusters are conserved. ► Avian herpesvirus microRNAs share seed sequences with microRNAs of other species. ► Mdv1-miR-M4 shares a seed sequence with gga-miR-155, and this seed sequence is also shared with kshv-miR-K12. ► The MDV1 meq microRNA cluster is related to MDV1 oncogenicity.