Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

Nature 474, 7350 (2011). doi:10.1038/nature10143

Authors: Shravan Kumar Mishra, Tim Ammon, Grzegorz M. Popowicz, Marcin Krajewski, Roland J. Nagel, Manuel Ares, Tad A. Holak & Stefan Jentsch

Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structural and

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