Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Publication year: 2011
Source: Cellular Signalling, In Press, Accepted Manuscript, Available online 13 June 2011

Tim T., Chiu , Thomas E., Jensen , Lykke, Sylow , Erik A., Richter , Amira, Klip

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.