Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary InterventionRelationship With Gene Polymorphisms and Clinical Outcome

Publication year: 2011
Source: Journal of the American College of Cardiology, Volume 57, Issue 25, 21 June 2011, Pages 2474-2483

Gianluca, Campo , Giovanni, Parrinello , Paolo, Ferraresi , Barbara, Lunghi , Matteo, Tebaldi , …

 Objectives: This study sought to investigate the evolving pattern over time of on-clopidogrel platelet reactivity (PR) and its relationship with genotype and clinical outcomes after percutaneous coronary intervention. Background: Whether on-clopidogrel PR and role of genotype differ over time is unknown. Methods: On-clopidogrel PR before percutaneous coronary intervention, and 1 and 6 months thereafter via VerifyNow P2Y12 (Accumetrics Inc., San Diego, California), CYP2C19*2, *17, CYP3A5*3, and ABCB1 polymorphisms were evaluated in 300 patients. Death, stroke, myocardial infarction, and bleedings were assessed up to 1 year. Results: On-clopidogrel PR varied significantly over time, being higher at baseline than at 1 and 6 months after. From baseline to 1…