Principles of activation and permeation in an anion-selective Cys-loop receptor

Principles of activation and permeation in an anion-selective Cys-loop receptor

Nature 474, 7349 (2011). doi:10.1038/nature10139

Authors: Ryan E. Hibbs & Eric Gouaux

Fast inhibitory neurotransmission is essential for nervous system function and is mediated by binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in the membranes of neurons. Neurotransmitter binding triggers a conformational change in the receptor, opening an intrinsic chloride channel and thereby