Non-invasive electrical stimulation of the brain (ESB) modifies the resting-state network connectivity of the primary motor cortex: A proof of concept fMRI study

Publication year: 2011
Source: Brain Research, In Press, Accepted Manuscript, Available online 13 June 2011

G., Alon , S.R., Roys , R.P., Gullapalli , J.D., Greenspan

An innovative method to obtain fMRI resting-state network maps during non-invasive electrical stimulation of the brain (ESB) was developed and tested. Five healthy volunteers participated in 2 fMRI sessions. In session one, a transcranial direct current stimulator (tDCS) was applied placing the positive electrode (31.5 cm2) over the right M1 of the cortex and the negative electrode (31.5 cm2) over the left supra-orbital area of the head. In session two, a monophasic pulsed current stimulator (tPCS) was applied using the identical electrode placement. Imaging was performed on a Siemens 3T Tim Trio scanner with a 12-channel head coil. At each…

 Research highlights: ► fMRI resting-state maps were obtained during non-invasive electrical brain stimulation. ► Direct current (tDCS) or pulsed current (tPCS) were applied over primary motor cortex. ► tDCS and tPCS appear to lower the R2 values and amplitude-time integral in M1 bilaterally. ► Anodal stimulation down regulates the motor cortex’s resting-state connectivity.