New antimicrobial therapies used against fungi present in subgingival sites—A brief review

Publication year: 2011
Source: Archives of Oral Biology, In Press, Corrected Proof, Available online 14 June 2011

Janaina Cássia Orlandi, Sardi , Ana Marisa Fusco, Almeida , Maria José Soares, Mendes Giannini

Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. The treatment of periodontal disease includes scaling and root planning (SRP) associated with proper oral hygiene. However, some patients may have negative responses to different therapeutic procedures, with a continuous loss of insertion, so the use of antimicrobials is needed as an adjuvant to SRP treatment. The use of a broad-spectrum antibiotic, such as tetracycline and metronidazole, as an aid in periodontal treatment has also been a factor for the development of…