Mitochondrial DNA copy number in peripheral blood in polycystic ovary syndrome

Publication year: 2011
Source: Metabolism, In Press, Corrected Proof, Available online 14 June 2011

Sang-Hee, Lee , Da-Jung, Chung , Hee-Sun, Lee , Tae-June, Kim , Myung-Hee, Kim , …

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and various metabolic diseases; and recently, elevated oxidative stress has been detected in PCOS. Mitochondria are highly susceptible to oxidative damage; and disordered mitochondrial function at the cellular level can impact whole-body metabolic homeostasis, leading to the hypothesis that abnormalities in markers of mitochondrial metabolism are related to PCOS. We compared mitochondrial DNA (mtDNA) copy number in women with and without PCOS and investigated the independent relationship between mtDNA copy number and PCOS after adjustment for metabolic parameters. Fifty women with PCOS and 60 age- and body mass index–matched healthy women…