Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

Nature 474, 7351 (2011). doi:10.1038/nature10212

Authors: Jan Paul Medema & Louis Vermeulen

The identification of intestinal stem cells as well as their malignant counterparts, colon cancer stem cells, has undergone rapid development in recent years. Under physiological conditions, intestinal homeostasis is a carefully balanced and efficient interplay between stem cells, their progeny and the microenvironment. These interactions