Large neighbourhood search algorithms for the founder sequence reconstruction problem

Publication year: 2012
Source: Computers & Operations Research, Volume 39, Issue 2, February 2012, Pages 213-224

Andrea, Roli , Stefano, Benedettini , Thomas, Stützle , Christian, Blum

The reconstruction of founder genetic sequences of a population is a relevant issue in evolutionary biology research. The problem consists in finding a biologically plausible set of genetic sequences (founders), which can be recombined to obtain the genetic sequences of the individuals of a given population. The reconstruction of these sequences can be modelled as a combinatorial optimisation problem in which one has to find a set of genetic sequences such that the individuals of the population under study can be obtained by recombining founder sequences minimising the number of recombinations. This problem is called the founder sequence reconstruction problem….