Intestinal homeostasis and its breakdown in inflammatory bowel disease

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Nature 474, 7351 (2011). doi:10.1038/nature10208

Authors: Kevin J. Maloy & Fiona Powrie

Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now