Immune Ring Formation Associated With Cytomegalovirus Endotheliitis

Publication year: 2011
Source: American Journal of Ophthalmology, In Press, Corrected Proof, Available online 14 June 2011

Soon-Phaik, Chee , Aliza, Jap

 Purpose: To describe immune ring (IR) formation as a manifestation of cytomegalovirus (CMV) endotheliitis. Design: Retrospective observational case series. Methods: Review of all consecutive CMV anterior uveitis and endotheliitis patients seen at the Singapore National Eye Centre for the occurrence of an IR. CMV infection was diagnosed by polymerase chain reaction analysis of the aqueous. Results: None of the 72 eyes with CMV anterior uveitis had an IR formation. Four episodes of IR formation were seen in 3 eyes (14.3%) of 21 cases of CMV-positive endotheliitis. All were unilateral and all 3 patients were human immunodeficiency virus negative middle-aged Chinese males. The IR developed 2 to 7…