Imaging of the Aortic Valve Using Fluorodeoxyglucose Positron Emission TomographyIncreased Valvular Fluorodeoxyglucose Uptake in Aortic Stenosis

Publication year: 2011
Source: Journal of the American College of Cardiology, Volume 57, Issue 25, 21 June 2011, Pages 2507-2515

Gergana, Marincheva-Savcheva , Sharath, Subramanian , Sadia, Qadir , Amparo, Figueroa , Quynh, Truong , …

 Objectives: Because fluorodeoxyglucose positron emission tomography (FDG-PET) imaging provides a noninvasive index of inflammation, we sought to assess whether FDG uptake in the aortic valve (AV) is increased in aortic stenosis (AS). Background: AS is associated with valvular inflammation. Methods: FDG-PET/computed tomography data were retrospectively evaluated in 84 patients (age 73 ± 9 years, 45% female), 42 patients with AS, and 42 age-matched controls. FDG uptake was determined within the AV while blinded to AS severity. Target-to-background ratio (TBR) was calculated as valvular/blood activity. Stenosis severity was established on echocardiography, and presence of AV calcification was independently assessed on computed tomography. Results: The aortic valve PET signal…