High frequency stimulation of the subthalamic nucleus acutely rescues motor deficits and neocortical movement representations following 6-hydroxydopamine administration in rats

Publication year: 2011
Source: Experimental Neurology, In Press, Accepted Manuscript, Available online 13 June 2011

Andrew R., Brown , Michael C., Antle , Bin, Hu , G. Campbell, Teskey

Loss of frontal neocortical activation is one of the main neurophysiological abnormalities of Parkinson’s disease (PD) and can be observed in rodent models of nigrostriatal degeneration. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus improves motor deficits in PD. However, it is unknown whether this general therapeutic effect is associated with a restoration of frontal output function. To address this question,chronic stimulating electrodes were implanted bilaterally into the subthalamic nuclei of adult rats that received either bilateral intrastriatal 6-hydroxydopamine (6-OHDA) or vehicle infusion to induce nigrostriatal degeneration. Forelimb use and locomotor activity was assessed based on the cylinder and…

 Highlights: ► 6-hydroxydopamine (6-OHDA) administration in rats impaired motor behaviour ► 6-OHDA infusion decreased forelimb motor map area and raised movement thresholds ► Subthalamic deep brain stimulation (STN DBS) reversed 6-OHDA behavioural deficits ► STN DBS rescues 6-OHDA deficits on forelimb motor map area and movement thresholds