Growth of limb muscle is dependent on skeletal-derived Indian hedgehog

Publication year: 2011
Source: Developmental Biology, In Press, Accepted Manuscript, Available online 13 June 2011

Yvette, Bren-Mattison , Melissa, Hausburg , Bradley B., Olwin

During embryogenesis, muscle and bone develop in close temporal and spatial proximity. We show that Indian Hedgehog, a bone-derived signaling molecule, participates in growth of skeletal muscle. In Ihh-/- embryos, skeletal muscle development appears abnormal at embryonic day 14.5 and at later ages through embryonic day 20.5, dramatic losses of hindlimb muscle occur. To further examine the role of Ihh in myogenesis, we manipulated Ihh expression in the developing chick hindlimb. Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh-/- mouse embryos. The reduction in muscle mass appears to be a direct…

 Research highlights: ► Coordination of skeletal and muscle development ► Regulation of secondary myogenesis by a bone-derived factor ► Ihh-mediated survival of fetal myoblasts during myogenesis