Genetics and pathogenesis of inflammatory bowel disease

Genetics and pathogenesis of inflammatory bowel disease

Nature 474, 7351 (2011). doi:10.1038/nature10209

Authors: Bernard Khor, Agnès Gardet & Ramnik J. Xavier

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and