ENALAPRIL TREATMENT DISCLOSES AN EARLY ROLE OF ANGIOTENSIN II IN INFLAMMATION- AND OXIDATIVE STRESS-RELATED MUSCLE DAMAGE IN DYSTROPHIC MDX MICE

Publication year: 2011
Source: Pharmacological Research, In Press, Accepted Manuscript, Available online 13 June 2011

Anna, Cozzoli , Beatrice, Nico , Valeriana Teresa, Sblendorio , Roberta Francesca, Capogrosso , Maria Maddalena, Dinardo , …

Inhibitors of angiotensin converting enzymes (ACE) are clinically used to control cardiomyopathy in patients of Duchenne muscular dystrophy. Various evidences suggest potential usefulness of long-term treatment with ACE inhibitors to reduce advanced fibrosis of dystrophic muscle in the mdx mouse model. However, angiotensin II is known to exert pro-inflammatory and pro-oxidative actions that might contribute to early events of dystrophic muscle degeneration. The present study has been aimed at evaluating the effects of an early treatment with enalapril on the pathology signs of exercised mdx mouse model. The effects of 1 and 5mg/kg enalapril i.p. for 4-8 weeks have been…