Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

Nature 474, 7349 (2011). doi:10.1038/nature10109

Authors: Gilles Phan, Han Remaut, Tao Wang, William J. Allen, Katharina F. Pirker, Andrey Lebedev, Nadine S. Henderson, Sebastian Geibel, Ender Volkan, Jun Yan, Micha B. A. Kunze, Jerome S. Pinkner, Bradley Ford, Christopher W. M. Kay, Huilin Li, Scott J. Hultgren, David G. Thanassi & Gabriel Waksman

Type 1 pili are the archetypal representative of a widespread class of adhesive multisubunit fibres in Gram-negative bacteria. During pilus assembly, subunits dock as chaperone-bound complexes to an usher, which catalyses their polymerization and mediates pilus translocation across the outer membrane. Here we report the

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