Cell biology: Stressful genetics in Crohn’s disease

Cell biology: Stressful genetics in Crohn’s disease

Nature 506, 7489 (2014). doi:10.1038/nature13060

Authors: Arthur Kaser & Richard S. Blumberg

A common variant of the autophagy protein ATG16L1 is a risk factor for Crohn’s disease. But the genetic alteration is revealed only when the protein is cleaved by the enzyme caspase 3 during cellular stress. See Article p.456