Graphene Electric Double Layer Capacitor with Ultra-High-Power Performance

Publication year: 2011
Source: Electrochimica Acta, In Press, Accepted Manuscript, Available online 13 June 2011

John R., Miller , R.A., Outlaw , B.C., Holloway

We have demonstrated, for the first time, efficient 120Hz filtering by an electric double layer capacitor (EDLC). The key to this ultra-high-power performance is electrodes made from vertically-oriented graphene nanosheets grown directly on metal current collectors. This design minimized both electronic and ionic resistance and produced capacitors having RC time-constants of less than 200μs. Significantly, graphene nanosheets have a preponderance of exposed edge planes that greatly increase stored charge over designs relying on basal plane surfaces. Collectively these factors make vertically-oriented graphene nanosheet electrodes ideally suited for producing high-frequency EDLCs. Capacitors constructed with these electrodes are predicted to be significantly…

Effects of Locations of a 3-D Design Object in a 3-D Radiant Furnace for Prescribed Uniform Thermal Conditions

Publication year: 2011
Source: Applied Thermal Engineering, In Press, Accepted Manuscript, Available online 13 June 2011

Ramchandra P., Chopade , Subhash C., Mishra , P., Mahanta , S., Maruyama

This article deals with the study of effects of locations for prescribed uniform thermal conditions ona 3-D design object (DO) placed on the bottom of a 3-D radiant furnace. For the desired uniform thermal conditions, importance of locations of the DO is exemplified. For a given power range of the panel heaters, for each of the three sizes of the DO, study is made for different possible locations. In each case, the heat flux distribution on the surfaces of DO is estimated. For a particular DO, the suitability of any location is judged by comparing the estimated heat flux distribution…

Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth

Publication year: 2011
Source: Cancer Cell, Volume 19, Issue 6, 14 June 2011, Pages 765-775

Annarita, Miluzio , Anne, Beugnet , Stefano, Grosso , Daniela, Brina , Marilena, Mancino , …

Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit formation. eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation delays tumorigenesis and reduces tumor growth in vivo. eIF6+/− mice resist to Myc-induced lymphomagenesis and have prolonged tumor-free survival and reduced tumor growth. eIF6+/− mice are also protected by p53 loss. Myc-driven lymphomas contain PKCβII and phosphorylated eIF6; eIF6 is phosphorylated by tumor-derived PKCβII, but not by the eIF4F activator mTORC1. Mutation of PKCβII phosphosite of eIF6 reduces tumor growth. Thus, eIF6 is a rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth. Modulation…

 Highlights: ► eIF6 is rate limiting for Myc-induced lymphomagenesis and tumor growth ► eIF6 phosphorylation is mTOR independent and PKC dependent ► Cells with eIF6S235A overexpression transform in vitro, but do not grow in vivo ► eIF6 is a potential mTOR-independent translational target for cancer therapy

Hypoxia modulates the effect of dihydroartemisinin on endothelial cells

Publication year: 2011
Source: Biochemical Pharmacology, In Press, Accepted Manuscript, Available online 13 June 2011

S., D’Alessandro , N., Basilico , Y., Corbett , D., Scaccabarozzi , F., Omodeo-Salè , …

Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic and anti-tumor activity. Hypoxia plays a crucial role both in severe malaria (as a consequence of the cytoadherence of infected erythrocytes to the microvasculature) and in cancer (due to the restricted blood supply in the growing tumour mass). However, the consequences of hypoxia onto the effects of artemisinins is under-researched.This study aimed at assessing how the inhibition of microvascular endothelial cell (HMEC-1) growth induced by dihydroartemisinin (DHA, an antimalarial drug and the active metabolite of currently in-use artemisinins) is affected by oxygen tension.Low doses of DHA (achieved in the…

prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border

Publication year: 2011
Source: Developmental Biology, In Press, Accepted Manuscript, Available online 13 June 2011

Laura, Hernandez-Lagunas , Davalyn, Powell , Jera, Law , Kelly, Grant , Kristin Bruk, Artinger

The zinc finger domain transcription factor prdm1a plays an integral role in the development of the neural plate border cell fates, including neural crest cells and Rohon-Beard (RB) sensory neurons. However, the mechanisms underlying prdm1a function cell fate specification is unknown. Here, we test more directly how prdm1a functions in this cell fate decision. Rather than affecting cell death or proliferation at the neural plate border, prdm1a acts explicitly on cell fate specification by counteracting olig4 expression in the neighboring interneuron domain. olig4 expression is expanded in prdm1a mutants and olig4 knockdown can rescue the reduced or abrogated neural crest…

 Research highlights: ► prdm1a acts explicitly on cell fate specification by counteracting olig4 expression in the neighboring interneuron domain. ► prdm1a in neural plate border-derived cell fates. ► prdm1a expression is upregulated in the absence of Notch function, and inhibiting Notch signaling fails to rescue prdm1a mutants. ► prdm1a functions downstream of Notch in the regulation of cell fate at the neural plate border and that Notch regulates the total number of progenitor cells at the neural plate border.

Inhomogeneous optoelectronic and microstructure property distribution across the substrate of ZnO:Al films deposited by room temperature magnetron sputtering

Publication year: 2011
Source: Applied Surface Science, In Press, Accepted Manuscript, Available online 13 June 2011

Tao, Wang , Xungang, Diao , Xuan, Wang

Aluminum doped zinc oxide (ZAO) films were deposited by direct current (D.C) reactive magnetron sputtering from a ZnO: Al2O3 (3wt. % Al2O3) ceramic target at room temperature. In order to explore the inhomogeneous property distribution across the substrate, the films were deposited with varied substrate-target distances (Ds) ranging from 2cm to 9cm. The experimental results obtained from Four-point probe, Spectrophotometer, Scanning electron microscope, X-ray diffractometer and Auger Electronic Spectrometer were analyzed to explore the nonuniform property distribution of the obtained ZAO films. The results confirmed that the films’ optoelectronic properties, crystallinity and surface morphology, etc., which were obtained from different…

Diagnosis of surface damage induced by air pollution on 20th-century concrete buildings

Publication year: 2011
Source: Atmospheric Environment, In Press, Accepted Manuscript, Available online 13 June 2011

I., Ozga , A., Bonazza , E., Bernardi , F., Tittarelli , O., Favoni , …

The present work focuses on the impact of anthropogenic multi-pollutants on modern concrete buildings exposed in two different European urban areas: Centennial Hall in Wroclaw (Poland) and Casa Galleria Vichi in Florence (Italy). Through a range of analytical techniques the complete characterization of the damage layer collected from the buildings under study has been achieved for the first time, including quantitative measurements of the carbon content. The experimental results allow the identification and prioritization of the air pollutants responsible for the surface deterioration, finding gypsum to be the main damage product on surfaces sheltered from rain runoff, with embedded particulate…

 Highlights: ► The research focused on the impact of multi-pollutants on concrete buildings. ► SO2 and particles emitted by combustion sources have priority in damage formation. ► Results show the correlation between building location and damage layer composition. ► Carbon fractions analyses was a key in finding pollutant sources causing damage. ► Elemental data processing allowed the identification of the origin of elements.

Modified subset simulation method for reliability analysis of structural systems

Publication year: 2011
Source: Structural Safety, Volume 33, Issues 4-5, July 2011, Pages 251-260

Feng, Miao , Michel, Ghosn

A “Regenerative Adaptive Subset Simulation” (RASS) method is proposed for performing the reliability analysis of complex structural systems. Proposed modifications to the classic subset simulation method include the implementation of advanced Markov Chain processes to combine the benefits of a Markov Chain regeneration process, a Delayed Rejection and Adaptive sample selection algorithms and a Componentwise sampling model. The proposed modifications help to overcome the limitations of the original Metropolis–Hasting algorithm used in the subset simulation which include the “burn-in problem” and the difficulty of the selection of the proposal probability function. Several illustrative examples are presented to demonstrate the efficiency…

 Highlights: ► A modified Markov-chain based simulation method called “Regenerative Adaptive Subset Simulation (RASS)” is described. ► The proposed RASS provides improvements to the classical Subset Simulation (SS) by incorporating several new features. ► RASS reduces the correlation between the samples through a regeneration algorithm. ► Updating the variances of the proposal distribution function in an adaptive algorithm improves the overall efficiency. ► Univariate proposal distribution functions help optimize the computational effort for high-dimension problems.

High-Order Discontinuous Galerkin Computation of Axisymmetric Transonic Flows in Safety Relief Valves

Publication year: 2011
Source: Computers & Fluids, In Press, Accepted Manuscript, Available online 13 June 2011

F., Bassi , F., Cecchi , N., Franchina , S., Rebay , M., Savini

This paper presents a discontinuous Galerkin (DG) discretization of the compressible RANS and k-ω turbulence model equations for two-dimensional axisymmetric flows. The developed code has been applied to investigate the transonic flow in safety relief valves.This new DG implementation has evolved from the DG method presented in [1]. An ”exact” Riemann solver is used to compute the interface numerical inviscid flux while the viscous flux discterization relies on the BRMPS scheme [2,3]. Control of oscillations of high-order solutions around shocks is obtained by means of a shock-capturing technique developed and assessed within the EU ADIGMA project [4].The code has been…