Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms

Publication year: 2011
Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 14 June 2011

Scott F., Stoltenberg , Melissa K., Lehmann , Christa C., Christ , Samantha L., Hersrud , Gareth E., Davies

 Background: Some of the genetic vulnerability for addiction may be mediated by impulsivity. This study investigated relationships among impulsivity, substance use problems and six neurexin-3 (NRXN3) polymorphisms. Neurexins (NRXNs) are presynaptic transmembrane proteins that play a role in the development and function of synapses. Methods: Impulsivity was assessed with the Barratt Impulsiveness Scale Version 11 (BIS-11), the Boredom Proneness Scale (BPS) and the TIME paradigm; alcohol problems with the Michigan Alcoholism Screening Test (MAST); drug problems with the Drug Abuse Screening Test (DAST-20); and regular tobacco use with a single question. Participants (n=439 Caucasians, 64.7% female) donated buccal cells for genotyping. Six NRXN3…