Alveolar progenitor and stem cells in lung development, renewal and cancer

Alveolar progenitor and stem cells in lung development, renewal and cancer

Nature 507, 7491 (2014). doi:10.1038/nature12930

Authors: Tushar J. Desai, Douglas G. Brownfield & Mark A. Krasnow

Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal, surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but recent studies propose other sources. Here we use molecular markers, lineage tracing and clonal analysis to map alveolar

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