Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice

Publication year: 2011
Source: Biochimica et Biophysica Acta (BBA) – Bioenergetics, In Press, Accepted Manuscript, Available online 13 June 2011

Orlagh M., Kelly , Richard K., Porter

Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present decrease by a half in thymus and a fifth in spleen after three weeks, probably reflecting the suckling to weaning transition. UCP3 protein levels increase ~3-fold in thymus on starvation, but expression levels in spleen were unaffected by starvation. Lack of UCP3 had little effect on thymus mass or thymocyte number . However, lack of UCP3 affected spleen mass and splenocyte number (in the fasted state) and…