A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

Nature 506, 7489 (2014). doi:10.1038/nature13044

Authors: Aditya Murthy, Yun Li, Ivan Peng, Mike Reichelt, Anand Kumar Katakam, Rajkumar Noubade, Merone Roose-Girma, Jason DeVoss, Lauri Diehl, Robert R. Graham & Menno van Lookeren Campagne

Crohn’s disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn’s disease. Numerous studies have demonstrated